【摘 要】
：
We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regener-ation after acetaminophen(APAP)hepatotoxicity.Here,we hypothesized that exogenous PA is also bene-ficial.To test that,we treated mice with a toxic APAP dose at 0 h,foll
【机 构】
：
Department of Pharmacology and Toxicology,College of Medicine,University of Arkansas for Medical Sci
论文部分内容阅读
We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regener-ation after acetaminophen(APAP)hepatotoxicity.Here,we hypothesized that exogenous PA is also bene-ficial.To test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)post-treatment.We then collected blood and liver at 6,24,and 52 h.Post-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAC)reduced injury more than NAC alone.Interestingly,PA did not affect canonical mechanisms of APAP toxicity.Instead,transcriptomics revealed that PA activated interleukin-6(IL-6)signaling in the liver.Consistent with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphoryla-tion increased in PA-treated mice.Furthermore,PA failed to protect against APAP in IL-6-deficient an-imals.Interestingly,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating IL-6.Surprisingly,however,exogenous PA did not alter regenera-tion,despite the importance of endogenous PA in liver repair,possibly due to its short half-life.These data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective ef-fects of IL-6 in this model.
其他文献
在研究砍花法香菇栽培之初始阶段时,史书只写了“以刀斧所砍之处,发现生长香菇,且不砍不出,乱砍乱出,若砍而不出,发声叹而以槌棒击树,谓之惊蕈……”.这一解释仍不够清晰.对砍花法的技术要点如树种、砍花、温湿度掌控,以及病虫鸟兽防治,烘干、储存等的形成过程进行了推测:用“火爆法”开采五金之矿,必须大量砍伐阔叶树硬质木材,以干柴刚炭作为采矿冶炼基础,而砍伐后截段、堆积、干燥等过程,无形中成了木腐菌孢子定植的优势场所.人们在采食各种蕈菌过程中,发现香菇无毒且具特殊香味,随着香菇在食物贫缺的采矿区风靡,成为珍品,从坑
目的 评估安徽省国家疾病监测点2019年死因数据网报质量.方法 参照CRVS医学死亡证明书质量快速评估工具技术指南(第3版),结合安徽省实际情况形成本次评估方案,采用分层整群随机抽样方法评估安徽省国家死因监测点2019年死因网报数据填报准确性.结果 2019年安徽省国家疾病监测点死因网报数据总准确率、身份证号、死因链、根本死因准确率分别为47.03％,98.18％、52.24％和83.54％.总准确率表现为农村点(49.69％)＞城市点(44.38％),县级以下医疗机构(53.96％)＞县级及以上(40.
在西安植物园老区的裸子植物区,生长着几十种松柏.进入冬季后,我去那里散步,偶尔就会碰见前来觅食的大尾巴松鼠.这种大眼睛、大门牙、腮帮子鼓鼓的似塞满松子的小小萌物,会冷不丁从树上哧溜一声下来,一溜烟儿钻进草丛里.它们灵活地上蹿下跳,在树上、地面寻找可以果腹的松子.
Rescuing cells from stress damage emerges a potential therapeutic strategy to combat myocardial infarction.Protocatechuic aldehyde(PCA)is a major phenolic acid in Chinese herb Danshen(SSalvia miltiorrhiza root).This study investigated whether PCA regulate
Dioxin-like molecules have been associated with endocrine disruption and liver disease.To better understand aryl hydrocarbon receptor(AHR)biology,metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body g
The cell cycle inhibitor P21 has been implicated in cell senescence and plays an important role in the injury-repair process following lung injury.Pulmonary fibrosis(PF)is a fibrotic lung disorder characterized by cell senescence in lung alveolar epitheli
The drug formulation design of self-emulsifying drug delivery systems(SEDDS)often re-quires numerous experiments,which are time-and money-consuming.This research aimed to rationally design the SEDDS formulation by the integrated computational and experime
Pyrrolizidine alkaloids(PAs)are the most common phytotoxins with documented human hepatotoxicity.PAs require metabolic activation by cytochromes P450 to generate toxic intermediates which bind to proteins and form protein adducts,thereby causing cytotoxic
Traditional chemotherapy exhibits a certain therapeutic effect toward malignant cancer,but easily induce tumor multidrug resistance(MDR),thereby resulting in the progress of tumor recurrence or metastasis.In this work,we deigned ternary hybrid nanodrugs(P
改革开放42年来,中国经济实现了年均9％以上的增长速度,创造了世界经济发展史上的奇迹.在这42年中,经济第一省(自治区、直辖市、特别行政区)的位置也曾数易其主.1979年,江苏超越上海,成为内地第一经济大省,在之后的11年间,除了1982、1983、1984、1985年山东以微弱优势超越江苏外,江苏有7年都保持着内地第一经济大省的地位.