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为探讨胃癌组织微血管计数 (MVC)和巨噬细胞炎症蛋白 1α(MIP 1α)之间及其与胃癌侵袭转移和预后的关系 ,笔者采用免疫组化染色检测 60例胃癌病理标本MVC计数和MIP 1α半定量表达情况及其与肿瘤临床病理参数和预后的关系。结果示MIP 1α的阳性表达与MVC呈密切正相关 (P<0 .0 1) ,胃癌MVC高计数组及MIP 1α高表达组生存率明显低于低计数组和低表达组 (均P <0 .0 1)。提示胃癌MIP 1α表达与胃癌血管生成及预后密切相关 ,检测MIP 1α可能有助于确定术后治疗方案及判断预后。
In order to investigate the relationship between gastric cancer microvessel count (MVD) and macrophage inflammatory protein 1α (MIP 1α) and its relationship with invasion, metastasis and prognosis of gastric carcinoma, immunohistochemical staining was used to detect the number of MVC and MIP 1α Semiquantitative expression and its relationship with clinicopathological parameters and prognosis of tumor. The results showed that the positive expression of MIP 1α was positively correlated with MVC (P <0.01). The survival rates of high-count MVC group and high-expression MIP 1α group were significantly lower than those of low-count group and low-expression group .0 1). It is suggested that the expression of MIP 1α in gastric cancer is closely related to the angiogenesis and prognosis of gastric cancer. Detecting MIP 1α may help to determine the postoperative treatment and prognosis.