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目的:观察参芪扶正注射液缓解视网膜母细胞瘤患儿化疗毒副反应的临床疗效。方法:选取我院2009年9月至2011年9月临床确诊为视网膜母细胞瘤,并要求化疗保存眼球或眼球摘除后病理检查需要化疗的200例患儿,随机抽取100例患儿为治疗组,化疗时应用参芪扶正注射液;另外100例患儿为对照组,化疗时不用参芪扶正注射液。采用CTV化疗方案(卡铂560 mg/m2、替尼泊苷200 mg/m2、长春新碱1.5 mg/m2),观察其化疗时及化疗后毒副反应。毒副反应按照“WHO化疗毒副作用分级标准”进行评估。结果:治疗组中性粒细胞减少、恶心呕吐和谷丙转氨酶增高的发生率均低于对照组,两组比较差异有统计学意义(P<0.05)。血小板减少、白细胞减少、血红蛋白降低、腹泻、便秘、发热、周围神经症状的发生率两组比较差异无统计学意义(P>0.05)。结论:参芪扶正注射液可以缓解视网膜母细胞瘤患儿化疗的毒副反应。
Objective: To observe the clinical effect of Shenqi Fuzheng injection on chemotherapy-induced side effects in children with retinoblastoma. Methods: From September 2009 to September 2011, our hospital clinically diagnosed as retinoblastoma, and asked chemotherapy for preservation of the eye or eye excision pathological examination of 200 patients needed chemotherapy, a random sample of 100 children were treated group , Chemotherapy Shenqi Fuzheng injection; the other 100 cases of children as a control group, chemotherapy without Shenqi Fuzheng injection. CTV chemotherapy (carboplatin 560 mg / m2, teniposide 200 mg / m2, vincristine 1.5 mg / m2) was used to observe the chemotherapy and chemotherapy side effects. Toxicity and side effects were evaluated in accordance with the WHO classification criteria for toxicological effects of chemotherapy. Results: The incidences of neutropenia, nausea and vomiting and alanine aminotransferase in treatment group were lower than those in control group. There was significant difference between the two groups (P <0.05). Thrombocytopenia, leukopenia, hemoglobin decreased, diarrhea, constipation, fever, peripheral neurological symptoms were no significant difference between the two groups (P> 0.05). Conclusion: Shenqi Fuzheng injection can relieve the side effects of chemotherapy in children with retinoblastoma.