论文部分内容阅读
为探讨开博通在急性心肌梗塞患者溶栓治疗过程中对血管内皮细胞功能的影响，观察了６８例发病后１２ｈ内入院的急性心肌梗塞（ＡＭＩ）患者，在溶栓治疗后随机分为开博通组和安慰剂组，开博通组在溶栓后立刻给予开博通，首剂６．２５ｍｇ／次，此后１２．５ｍｇ／次，２次／天；于口服开博通前即刻及之后第２４ｈ和４８ｈ测定内皮素（ＥＴ）、前列环素（ＰＧＩ２）的代谢产物６－酮－前列腺素－Ｆｌａ（６－Ｋｅｔｏ－ＰＧＦＩａ）和血栓素Ａ２（ＴＸＡ２）的代谢产物血栓素Ｂ２（ＴＸＢ２）的浓度，并计算６－Ｋｅｔｏ－ＰＧＦ１ａ／ＴＸＢ２的比值，设安慰剂组作为对照。结果发现开博通可明显降低未通患者ＥＴ浓度，而再通患者的ＥＴ水平不受影响，明显地降低ＴＸＢ２（Ｐ＜０．０５）的水平，轻度降低６－Ｋｅｔｏ－ＰＧＦ１ａ水平（Ｐ＞０．０５），使６－Ｋｅｔｏ－ＰＧＦ１ａ／ＴＸＢ２（Ｋ／Ｔ）比值明显增高（Ｐ＜０．０５）。提示在ＡＭＩ患者溶栓治疗同时应用开博通，可纠正Ｋ／Ｔ比例失调，对ＡＭＩ产生治疗作用。
To investigate the effect of Kaibong tong on the function of vascular endothelial cells during thrombolytic therapy in patients with acute myocardial infarction, 68 patients with acute myocardial infarction (AMI) admitted within 12 hours after onset were randomly divided into open Broadcom group and placebo group, Kaibutong group immediately after thrombolysis Kaibutong, the first dose of 6.25mg / times, since then 12.5mg / time, 2 times / day; oral propafenone immediately and The metabolites of endothelin (ET) and prostacyclin (PGI2), the metabolites of 6-keto-prostaglandin-F1a (6-Keto-PGFIa) and thromboxane A2 (TXA2) TXB2) concentrations, and calculate the 6-Keto-PGF1a / TXB2 ratio, placebo group as a control. Keto-PGF1a levels were significantly lower in patients with recanalization than in those without recanalization (P <0.05) > 0.05), and the ratio of 6-Keto-PGF1a / TXB2 (K / T) was significantly increased (P <0.05). Prompt thrombolytic therapy in patients with AMI at the same time open Kaitong Tong, K / T can correct the imbalance of the AMI have a therapeutic effect.