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1名33岁和1名18岁男性急性淋巴细胞白血病患者,给予长春新碱、柔红霉素、环磷酰胺、门冬酰胺酶、地塞米松(VDCLP)方案化疗。于化疗第19天停用其他药,继续静脉滴注门冬酰胺酶1万U,1次/d,地塞米松10mg,1次/d。用药5d后,患者出现口渴、口干、多饮、多尿等症状。实验室检查示:空腹血糖>30mmol/L,尿糖(++++)。停用2药,经胰岛素治疗后,患者空腹血糖恢复正常。
One 33-year-old and one 18-year-old man with acute lymphoblastic leukemia received vincristine, daunorubicin, cyclophosphamide, asparaginase, and dexamethasone (VDCLP) regimen. On the 19th day of chemotherapy, other drugs were discontinued, and asphyxia 1 000 U, once a day, dexamethasone 10 mg, once a day. 5d after treatment, patients with thirst, dry mouth, polydipsia, polyuria and other symptoms. Laboratory tests showed: fasting blood glucose> 30mmol / L, urine sugar (++++). Disable 2 drugs, after insulin treatment, patients with fasting blood glucose returned to normal.