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文献报道,伴有胆汁郁积的慢活肝比无胆汁郁积者更易演变成肝硬化,并有早期死亡趋势。我院汪承柏等经多年探索,采用凉血活血重用赤芍治疗长期高黄疸郁积性慢性肝炎取得显著退黄效果。为进一步探索本药方疗效,本文对5例治疗后,肝穿活检标本进行电镜观察,并对其中3例进行治疗前后对比。结果表明,治疗后胆汁郁积基本消除,同时肝超微结构亦明显改善。对象与方法 5例经临床、生化及病理诊断为乙型慢活肝合并胆汁郁积。所有病例均单用凉血活血中药汤剂,于用药前通过腹腔镜采取肝活检标本,服药后当胆红质降至5mg以下时,再活检复查。其中王×于第二次肝穿后60天又做第三次肝穿。活检组织制备成电镜标本观察。
Reported in the literature, chronic liver accompanied by cholestasis more likely to evolve into cirrhosis than those without cholestasis, and early mortality trends. Our hospital Wang Chengbai, after many years of exploration, the use of red blood peppers cool paeoniae rubra long-term treatment of chronic jaundice cholestatic significant yellowing effect. In order to further explore the efficacy of the prescription, this article on 5 cases of treatment, liver biopsy specimens were observed by electron microscopy, and three cases before and after treatment compared. The results show that the treatment of cholestasis basically eliminated, while liver ultrastructure was also significantly improved. Subjects and methods 5 cases of clinical, biochemical and pathological diagnosis of slow-B liver activity with cholestasis. All cases were single with cooling blood and activating blood medicine decoction, before taking the drug by laparoscopic biopsy specimens, after taking the drug when the bilirubin dropped to 5mg or less, and then biopsy review. Which Wang × in the second liver after 60 days to do the third liver wear. Biopsy specimens were prepared for electron microscopy.