论文部分内容阅读
目的:观察通塞脉片治疗糖尿病下肢血管病变的临床疗效。方法:选择糖尿病下肢血管病变患者66例,随机分为治疗组36例、对照组30例。治疗组口服通塞脉片治疗;对照组口服甲钴胺片治疗。结果:总有效率治疗组为91.67%,对照组为60.00%,2组比较,差异有非常显著性意义(P<0.01),治疗组疗效优于对照组。治疗后治疗组全血黏度高切、低切及血浆黏度、红细胞聚集指数、纤维蛋白原均明显降低,对照组无明显改善,2组比较,差异均有非常显著性意义(P<0.01)。治疗后治疗组足背动脉血流量及踝/肱动脉血压比值明显升高,对照组无明显改善,2组比较,差异均有非常显著性意义(P<0.01)。结论:通塞脉片能有效改善糖尿病下肢血管病变临床症状和血流动力学。
Objective: To observe the clinical curative effect of Tongsaimaipian on diabetic lower extremity vascular disease. Methods: Sixty-six patients with diabetic lower extremity vascular disease were randomly divided into treatment group (36 cases) and control group (30 cases). The treatment group oral Tongsai Mai tablets; the control group oral methylcobalamin tablets. Results: The total effective rate was 91.67% in the treatment group and 60.00% in the control group. There was significant difference between the two groups (P <0.01). The curative effect in the treatment group was better than that in the control group. After treatment, the whole blood viscosity, high shear rate, low shear rate and plasma viscosity, erythrocyte aggregation index and fibrinogen of the treatment group were significantly decreased, while no significant improvement was found in the control group. The differences between the two groups were significant (P <0.01). After treatment, the ratio of blood flow to the dorsalis pedis artery and the ratio of ankle / brachial artery blood pressure in the treatment group was significantly increased, but no significant improvement in the control group. The differences between the two groups were significant (P <0.01). Conclusion: Tongsaimaili tablet can effectively improve the clinical symptoms and hemodynamics of diabetic lower extremity vascular lesions.