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转化生长因子α、β(TGF -α、TGF - β)与卵巢癌的发生、发展、预后均有关系。TGF -α是上皮来源卵巢癌细胞的一种自分泌生长因子 ,与表皮生长因子受体 (EGFR)有高度亲和力。实验证明大多数卵巢癌细胞系中有TGF -α表达 ,部分卵巢癌细胞系可被外源性TGF -α促进生长 ,部分可被TGF -α抗体抑制生长。TGF -α/EGFR共同表达组病人存活率最低 ,TGF -α/EGFR水平增高提示病人预后不良及生存时间缩短。TGF - β是一种重要的负性生长调节因子 ,功能多样。实验证明体外卵巢癌细胞系的增殖率与TGF - β分泌量呈负相关。有人提出将TGF - β用于调节病人免疫反应而对治疗提供帮助
Transforming growth factor alpha, beta (TGF - alpha, TGF - beta) is associated with the occurrence, development and prognosis of ovarian cancer. TGF-α is an autocrine growth factor of epithelial-derived ovarian cancer cells and has a high affinity for epidermal growth factor receptor (EGFR). Experiments show that the majority of ovarian cancer cell lines have TGF-α expression, some ovarian cancer cell lines can be exogenous TGF-α to promote growth, in part, can be TGF-α antibody inhibition of growth. The co-expression of TGF-α / EGFR group, the lowest survival rate of patients, TGF-α / EGFR levels suggest that patients with poor prognosis and shortened survival time. TGF - β is an important negative growth regulator with diverse functions. Experiments show that the proliferation rate of ovarian cancer cell lines in vitro is negatively correlated with the secretion of TGF - β. It has been suggested that TGF - β may be used to help regulate the immune response in patients