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作者研究了不同透析膜、不同透析方法对尿毒症大、中、小分了毒物的清除情况。发现铜仿膜(CUP)做血液透析(HD)、聚砜膜(PS)作血液透析滤过(HDF)及高流量透析(HFD)对小分子物质清除均佳;TACurea均小于50mg。HD对中分子物质(MMS)有一定清除作用,对β_2m无清除效果。HDF对NlMS及β_2m清除最佳。HFD对MMS及β_2m清除较HDF及血液滤过(HF)差。HF对MMS及β_2m有良好清除效果,但对血尿素氮(BUN)及肌酐(Cr)清除较差CAPD每日清除MMS及β_2m-微球蛋白(β_2m)量不如HF、HDF及HFD,但每周清除量是HD的2～4倍,是无条件进行HF或HDF单位清除MMS及β_2m的良好方法。
The author studied different dialysis membranes, different dialysis methods uremic large, medium and small points of the removal of poisons. It was found that CUP did good on hemodialysis (HD), polysulfone membrane (PS) on hemodiafiltration (HDF) and high-flow dialysis (HFD) for small molecule clearance; TACurea was less than 50 mg. HD on the molecular substances (MMS) have a certain clearance, no clearance of β_2m effect. HDF removes NlMS and β_2m best. HFD clearance of MMS and β_2m is worse than HDF and hemofiltration (HF). HF had good clearance of MMS and β_2m, but poor clearance of blood urea nitrogen (BUN) and creatinine (Cr). The daily clearance of MMS and β_2m-microglobulin (β_2m) in CAPD was less than HF, HDF and HFD Weekly clearance is 2 to 4 times that of HD, and is a good way to unconditionally remove MMS and β_2m from HF or HDF units.