STUDY OF RADIOIMMUNOIMAGING WITH MONOCLONAL ANTIBODY AGAINST THE PATIENTS WITH SCLC

• 作 者: 李斯德 洪锦心 田培坤 莫忠根 苗积生 谈立松 吴姚裘 章英剑 蒋尚英 蒋茂松 娄葆金
• 机 构: Shanghai Cancer Institute,Shanghai Cancer Institute,Shanghai Cancer Institute,Shanghai Cancer Instit
• 出 处: Chinese Journal of Cancer Research
• 发表日期: 1991年04期
• 关键词: camera affinity nude monoclonal IgG latter proving possibility specificity besid

It is an Innovative way to diagnose with cancer with monoclonal antibody (MAb) in vivo. 1-3 After proving MAb 2F7 (IgG2a) had a higher affinity and better specificity to human small cell lung cancer cells in vitro, 4.5 and gave a very clear cut γ- camera pictures for the xenografts of human small cell lung cancer (SCLC) born by nude mice, 6 the possibility of clinical radioimmunoimaging was studied with the MAb 2F7 and its fragment F (ab’) 2.

It is an innovative way to diagnose with cancer with monoclonal antibody (MAb) in vivo. 1-3 After proving MAb 2F7 (IgG2a) had a higher affinity and better specificity to human small cell lung cancer cells in vitro, 4.5 and gave a very Clear cut gamma-camera pictures for the xenografts of human small cell lung cancer (SCLC) born by nude mice, 6 the possibility of clinical radioimmunoimaging was studied with the MAb 2F7 and its fragment F (ab’) 2.