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目的：明确内源性雌激素（Ｅ２）和生长因子（ＥＧＦＲ）在大肠癌中的作用及相互关系。方法：免疫组化检测４８例大肠癌内源性Ｅ２、ＥＧＦＲ和ＰＣＮＡ的表达。结果：内源性Ｅ２阳性２９（６０．４％）例，其阳性细胞平均百分率为４１．１％，与肿瘤淋巴结转移呈负相关（Ｐ＜０．０５）。ＥＧＦＲ过表达３２（６６．７％）例，ＰＣＮＡ增殖指数高，且两者均与肿瘤淋巴结转移呈正相关（Ｐ＜０．０５）。内源性Ｅ２阳性细胞百分率与ＥＧＦＲ过表达呈负相关（Ｐ＜０．０５）；ＥＧＦＲ与ＰＣＮＡ的表达呈正相关（Ｐ＜０．０５）。结论：内源性Ｅ２阴性或阳性细胞数目少的大肠癌受生长因子影响大，瘤细胞增殖分裂能力强，易发生浸润转移
Objective: To clarify the role of endogenous estrogen (E2) and growth factor (EGFR) in colorectal cancer and their relationship. Methods: The expression of endogenous E2, EGFR and PCNA in 48 colorectal cancers was detected by immunohistochemistry. RESULTS: The average percentage of positive cells was 41.1% in 29 (60.4%) patients with endogenous E2, which was negatively correlated with tumor lymph node metastasis (P<0.05). Overexpression of EGFR in 32 cases (66.7%) showed high PCNA proliferation index, and both had a positive correlation with lymph node metastasis (P<0.05). The percentage of endogenous E2 positive cells was negatively correlated with EGFR overexpression (P<0.05), and there was a positive correlation between EGFR and PCNA expression (P<0.05). CONCLUSIONS: Colorectal cancers with a small number of endogenous E2 negative or positive cells are greatly affected by growth factors. They have strong proliferative and proliferative capacity and are prone to invasive metastasis.