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目的探讨胃癌组织中高迁移率族蛋白B1(HMGB1)和晚期糖基化终末产物受体(RAGE)蛋白的表达及临床意义。方法选取2013年6月至2016年6月间青岛市胶州中心医院收治的230例胃癌患者,均行手术治疗,取胃癌组织作为观察组,取癌旁正常组织作为对照组。检测两组组织内HMGB1和RAGE的表达情况,观察其与临床病理参数的关系,采用Spearman相关分析法分析HMGB1和RAGE的相关性。结果观察组中HMGB1和RAGE阳性表达率分别为43.9%(101/230)和44.8%(103/230),对照组中HMGB1和RAGE阳性表达率分别为17.4%(40/230)和19.6%(45/230),两组比较,差异有统计学意义(P<0.05)。HMGB1在不同TNM分期和有无淋巴结转移患者间的表达比较,差异有统计学意义(P<0.05),RAGE与有无淋巴结转移患者间的表达比较,差异有统计学意义(P<0.05)。Spearman相关分析显示,HMGB1和RAGE表达呈正相关关系。结论胃癌组织中的HMGB1和RAGE会呈高表达,其对胃癌转移和浸润有预测作用,且HMGB1和RAGE存在正相关关系。
Objective To investigate the expression of high mobility group box 1 (HMGB1) and advanced glycation end product receptor (RAGE) proteins in gastric carcinoma and its clinical significance. Methods Totally 230 gastric cancer patients admitted from June 2013 to June 2016 in Qingdao Jiaozhou Central Hospital were treated with surgery. Gastric cancer tissue was taken as observation group and normal tissue adjacent to tumor was taken as control group. The expression of HMGB1 and RAGE in both groups were detected. The relationship between HMGB1 and RAGE was observed. The correlation between HMGB1 and RAGE was analyzed by Spearman correlation analysis. Results The positive rates of HMGB1 and RAGE in the observation group were 43.9% (101/230) and 44.8% (103/230) respectively, while the positive rates of HMGB1 and RAGE in the control group were 17.4% (40/230) and 19.6% 45/230). There was significant difference between the two groups (P <0.05). The expression of HMGB1 was significantly different between patients with different TNM stages and with or without lymph node metastasis (P <0.05). The expression of HMGB1 in patients with and without lymph node metastasis was significantly different (P <0.05). Spearman correlation analysis showed that the expression of HMGB1 and RAGE were positively correlated. Conclusion HMGB1 and RAGE in gastric cancer tissues are highly expressed, which may predict the metastasis and invasion of gastric cancer. There is a positive correlation between HMGB1 and RAGE.