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邻苯二甲酸酯(phthalates,PAEs)是塑胶工业中最为常用的增塑剂和软化剂。该物质可通过食品包装材料直接迁移到食品中,也可通过含有该物质的塑料制品迁移到环境中,对空气、水、土壤和食品造成污染而危害人类的健康。PAEs具有雌激素效应,对神经系统具有毒性作用。笔者就PAEs的神经毒性作用及其机制的研究进展作一综述,为今后对该物质的毒理学研究提供参考。
Phthalates (PAEs) are the most commonly used plasticizers and softeners in the plastics industry. The substance can be directly transferred to the food through the food packaging material, or it can be endangering human health through the migration of plastic products containing the substance into the environment, causing pollution to air, water, soil and food. PAEs have estrogenic effects and have toxic effects on the nervous system. The author reviews the progress of the neurotoxic effects of PAEs and its mechanism, and provides a reference for the toxicological study of this substance in the future.