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2名老年女性患者给予鲑鱼降钙素注射液治疗时出现腹部绞痛、腹泻、心律失常等不良反应。第1例为67岁女性,因腰椎间盘退行性病变、骨质疏松入院,给予葡萄糖酸钙1g,2次/d口服,并在皮肤试验呈阴性后给予肌内注射鲑鱼降钙素50IU,1次/d。注射后30min出现腹部绞痛,排黄色糊状便1次;2h出现心悸,心电图检查示:心律不齐、阵发性室性心动过速、偶发房性期前收缩,持续约1h后症状消失。连续注射3d,症状加重并出现双眼睑水肿,遂改为每周注射1次,注射2周后仍有上述症状,即停药,5d后症状缓解,再行心电图检查正常。第2例为65岁女性,以“腰椎间盘脱出、双膝关节退行性变”入院。实验室检查:血钙2.02mmol/L。于皮试阴性后,给予肌内注射鲑鱼降钙素50IU。注射后2h出现腹部绞痛、尿频、尿急、腹泻。心电图示:窦性心动过速。6h后症状自行缓解,未进行第2次注射。
Two elderly female patients given salmon calcitonin injection treatment of abdominal cramps, diarrhea, arrhythmia and other adverse reactions. The first case was a 67-year-old woman who was admitted to hospital for lumbar disc degenerative disease and osteoporosis. She was administered orally with 1 g of calcium gluconate twice daily and intramuscularly with salmon calcitonin 50 IU Times / d. Abdominal cramps 30min after injection, row of yellow paste 1; 2h palpitations, ECG showed: arrhythmia, paroxysmal supraventricular tachycardia, occasional atrial contraction, lasted about 1h after the symptoms disappeared . Continuous injection of 3d, the symptoms aggravated and double eyelid edema, then changed to weekly injection, injection 2 weeks after the above symptoms are still there, that is, withdrawal, symptoms after 5d, and then normal ECG. The second case was a 65-year-old woman who was hospitalized with “prolapse of the lumbar intervertebral disc and degeneration of double knees ”. Laboratory tests: calcium 2.02mmol / L. After skin test negative, intramuscular salmon calcitonin 50 IU was given. 2h after injection abdominal cramps, frequent urination, urgency, diarrhea. ECG shows: sinus tachycardia. After 6h, the symptom relieved itself and did not make the second injection.