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[目的]评价PF方案化疗联合肿瘤深部射频热疗对晚期食管癌的近期疗效和免疫功能的影响。[方法]随机将45例晚期食管癌患者分为化疗联合射频热疗组(热化组)23例和单纯化疗(单化组)22例。比较两组近期疗效、免疫功能和不良反应。[结果]单化组和热化组的有效率分别为31.82%和39.13%,疾病控制率分别为59.09%和69.57%,平均肿瘤进展时间分别为5.3±2.4个月和6.5±2.5个月,均无统计学差异;热化组NK细胞上升,Karnofsky评分改善。[结论]射频热疗联合化疗是治疗晚期食管癌的有效方法之一,患者耐受性较好,是值得应用的综合治疗方法。
[Objective] To evaluate the effect of PF regimen combined with deep tumor radiofrequency thermotherapy on the short-term efficacy and immune function of advanced esophageal cancer. [Methods] Forty-five patients with advanced esophageal cancer were randomly divided into chemotherapy and radiofrequency ablation group (heating group), 23 patients and chemotherapy alone group (22 patients). Short-term efficacy, immune function and adverse reactions were compared between the two groups. [Results] The effective rate of the chemotherapy group and the heating group were respectively 31.82% and 39.13%, the disease control rates were 59.09% and 69.57%, the average tumor progression time was 5.3 ± 2.4 months and 6.5 ± 2.5 months respectively, No statistical difference was found between the two groups. The number of NK cells in heating group increased and Karnofsky score improved. [Conclusion] Radiofrequency thermotherapy combined with chemotherapy is one of the effective methods for the treatment of advanced esophageal cancer. Patients are well tolerated and it is a comprehensive treatment worthy of application.