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HLA(Human Leucocyte Antigen)是一种人类同种异体抗原,分布在真核细胞和血小板表面,作为机体个体性的标记。控制HLA抗原的基因位点在第6对染色体短臂上。Lilly(1964)报告小鼠H-2型与自血病病毒病因的关系,Amiel(1067)观察到何杰金淋巴瘤40抗原频率增高的情况,近年来一些作者注意到HLA与急性白血病、慢性型血小板减少性紫癜等血液病的关系。本文调查了我国人的急淋与HLA-A、B、C、DR之间的关系。材料与方法 1.病例选择及一般资料:临床症状、查体、血象、骨髓细胞学和血细胞化学检查结果确诊为急淋。经联合化疗缓解,停化疗一周后抽静脉血送检。25例中男17,女8例。年龄范围为3—70岁,<12岁者7例,13—15岁者5例,>15岁者13例。并调查了78名
HLA (Human Leucocyte Antigen) is a human allogeneic antigen that is distributed on the surface of eukaryotic cells and platelets as an individual marker of the body. The locus controlling HLA antigens is on the 6th chromosome short arm. Lilly (1964) reported the relationship between mouse H-2 and the etiology of the virus, and Amiel (1067) observed an increase in the frequency of Hodgkin’s lymphoma 40 antigen. In recent years, some authors have noticed that HLA is associated with acute leukemia, chronic Thrombocytopenic purpura and other blood diseases. This article investigates the relationship between Chinese acute lymphoblastic and HLA-A, B, C and DR. Materials and methods 1. Case selection and general information: clinical symptoms, physical examination, blood, bone marrow cytology and cytochemistry findings were diagnosed as acute lymph node. After the combination of chemotherapy to relieve, stop bleeding after a week of venous blood test. 25 cases of male 17, female 8 cases. The age range is 3-70 years old, <12 years old in 7 cases, 13-15 years old in 5 cases,> 15 years old in 13 cases. And surveyed 78