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目的探讨氟桂利嗪治疗癫合并偏头痛患者的临床疗效及安全性。方法选取2013年1月至2015年2月黑龙江省医院收治的癫共患偏头痛患者50例作为研究对象,将其完全随机均分为两组,对照组患者应用抗癫药物治疗,观察组患者在对照组治疗基础上联合氟桂利嗪进行治疗。比较两组患者治疗1年后的临床效果、用药后的不良反应,以此分析用药安全性。结果观察组患者对病情控制有效率明显优于对照组,差异有统计学意义(P<0.05)。治疗1年后观察组患者出现不良反应2例,对照组出现不良反应4例,差异无统计学意义(P>0.05)。结论癫合并偏头痛患者应用抗癫药物治疗时,联合小剂量氟桂利嗪可有效控制病情,疗效极佳,但有少量不良反应出现。
Objective To investigate the clinical efficacy and safety of flunarizine in patients with epilepsy complicated with migraine. Methods Fifty patients with epilepsy migraine who were admitted to Heilongjiang Provincial Hospital from January 2013 to February 2015 were randomly divided into two groups randomly. Patients in the control group were treated with antiepileptic drugs and observed Patients in the control group were treated with flunarizine on the basis of the control group. The clinical effects of the two groups of patients after 1 year of treatment were compared, and the adverse reactions after treatment were compared to analyze the safety of medication. Results The effective rate of the patients in the observation group was significantly better than that of the control group, with significant difference (P <0.05). One year after treatment, adverse reactions in the observation group were observed in 2 patients and in the control group in 4 patients. The difference was not statistically significant (P> 0.05). Conclusion Epilepsy combined with migraine patients treated with anti-epileptic drugs, combined with low-dose flunarizine can effectively control the disease, the effect is excellent, but a small amount of adverse reactions.