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非那西丁是常用的解热镇痛药,一般认为毒性较低,效果良好,因而都愿意使用。但对于其易于中毒而产生变性血红蛋白血症的作用常被忽视,特别是小婴儿对本药敏感更为缺乏警惕,因此发生中毒的报告屡见不鲜。非那西丁内服后,吸收迅速而完全,一般在1-2小时后血中可达到最高浓度,5小时内代谢完全。其大部分代谢产物为对乙酰氨基酚,一小部分去乙酰基变为对氨基苯乙醚。前者与硫酸及葡萄糖醛酸结合由尿中排
Phenacetin is commonly used antipyretic analgesics, generally considered less toxic, the effect is good, and therefore are willing to use. However, its susceptibility to degeneration of hemoglobinemia is often neglected, especially for small infants who are less sensitive to the drug. Therefore, the report of poisoning is not uncommon. After phenacetin oral administration, the absorption quickly and completely, usually 1-2 hours after the blood can reach the highest concentration, 5 hours metabolism completely. Most of its metabolites are acetaminophen, a small portion of the deacetyl to p-aminophenylether. The former with sulfuric acid and glucuronic acid by the urine row