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体内试验给大鼠注射半胱胺或5-羟色胺均能使肥大细胞吸收~(45)Ca~(++)明显增加,在药物最大有效期内作用最强,并且5-羟色胺的作用强度及维持时间都较强。在Ca离子载体A-23187作用下,肥大细胞中~(45)Ca~(++)吸收与组织胺释放呈同步关系,说明这两个过程紧密相关,但在体外实验中,不同类型辐射防护剂对钙的吸收有不同的作用。例如含硫化合物半胱胺和胱胺对~(45)Ca~(++)的吸收没有影响,而给生物胺制剂5-羟色胺或组织胺时,~(45)Ca~(++)吸收分别较对照
In vivo, rats injected cysteamine or serotonin can make mast cells uptake ~ (45) Ca ~ (++) increased significantly in the maximum effective period of the drug strongest, and the role of serotonin intensity and maintenance Time is strong. The Ca ~ (45) Ca ~ (++) uptake in mast cells synchronizes with histamine release under the action of Ca ionophore A-23187, indicating that these two processes are closely related, but in vitro experiments, different types of radiation protection Agents on the absorption of calcium have different effects. For example, the sulfur compounds cysteamine and cystamine have no effect on the absorption of ~ (45) Ca ~ (++), while ~ (45) Ca ~ (++) absorption of biogenic amines when preparing serotonin or histamine Respectively, compared with the control