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目的观察帕罗西汀对功能性消化不良患者消化不良症状及生活质量的影响。方法按照罗马II标准选择156例功能性消化不良患者随机分为两组,对照组78例给予多潘立酮(10mg tid);治疗组78例在多潘立酮治疗的基础上加抗抑郁药-盐酸帕罗西汀(10mg qd)。疗程8周,评定治疗前后患者的生活质量评分(生活质量指数问卷QL-INDEX)和消化不良症状评分。结果8周后消化不良症状评分治疗组显著低于对照组(P<0.01);生活质量评分治疗组明显高于对照组(P<0.05)。结论对功能性消化不良患者,小剂量盐酸帕罗西汀能明显改善患者的消化不良症状及生活质量。
Objective To observe the effect of paroxetine on dyspeptic symptoms and quality of life in patients with functional dyspepsia. Methods A total of 156 patients with functional dyspepsia were selected according to the Roman II criteria and randomly divided into two groups. 78 patients in the control group were given domperidone (10 mg tid). In the treatment group, 78 patients were treated with domperidone plus paroxetine hydrochloride (10 mg qd). The course of treatment was 8 weeks. The quality of life scores (QL-INDEX) and dyspeptic symptoms scores of patients before and after treatment were evaluated. Results After 8 weeks, the score of dyspeptic symptom in treatment group was significantly lower than that in control group (P <0.01). The quality of life score in treatment group was significantly higher than that in control group (P <0.05). Conclusions For patients with functional dyspepsia, low dose paroxetine hydrochloride can significantly improve the symptoms and quality of life of patients with dyspepsia.