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肿瘤干细胞(cancer stem cell,CSC)是恶性肿瘤复发及对化疗药物耐药的根源。自CSC学说提出以来,有关CSC表面标志物的研究越来越被临床重视。CSC表面标志物有助于分离纯化CSC以进一步研究CSC生物学功能,且可作为预测癌症复发及耐药的指标,指导临床决策。目前,寻找卵巢CSC和非CSC间差异性表达的标志物是卵巢癌治疗领域的难题。本文就CSC表面标志物在卵巢癌应用中的研究进展作一综述。
Cancer stem cells (CSCs) are the source of malignant tumor recurrence and chemoresistance. Since the CSC doctrine was proposed, the CSC surface marker research has been increasingly clinically valued. CSC surface markers contribute to the isolation and purification of CSCs for further study of CSC biological function, and can be used as an indicator of cancer recurrence and drug resistance to guide clinical decision-making. At present, the search for markers of differentially expressed ovarian CSC and non-CSC is a difficult problem in the treatment of ovarian cancer. This article reviews the research progress of CSC surface markers in the application of ovarian cancer.