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呼吸道病毒感染可能促进慢性支气管炎、肺气肿和其他慢性阻塞性肺病(COPD)患者气道功能进行性恶化,这一假设引起了研究者的兴趣。1967年作者开始进行一个长期的前瞻性研究,即研究细菌、病毒和支原体感染对 COPD 患者临床病程和肺功能恶化速度的影响。本文评价了84例 COPD 患者和8例正常受试者100次呼吸道病毒感染对时间肺活量(FVC)和第1秒最大呼气量(FEV_1)的短期和长期影响。一些病毒感染伴有 FVC 和/或 FEV_1短期轻度减少25～300ml。且仅在感染后90天内可检测出来。在流感病毒感染后肺功能异常改变最大,且 FEV_1平均急剧改变(-118.5ml)显著超过预期者(-15.2ml,P=0.03)。分析此期内8次感染后实测值的改变为
The hypothesis has drawn researchers’ interest that respiratory virus infection may promote the progressive deterioration of airway function in chronic bronchitis, emphysema and other patients with chronic obstructive pulmonary disease (COPD). In 1967, the authors began a long-term, prospective study examining the effects of bacterial, viral, and mycoplasmal infections on the clinical course of COPD and the rate of deterioration in lung function. This study evaluated the short-term and long-term effects of 100 respiratory viral infections in 84 COPD patients and 8 normal subjects on time-vital capacity (FVC) and maximum expiratory volume in 1 second (FEV_1). Some virus infections with FVC and / or FEV 1 short term mild reduction of 25 ~ 300ml. It is detectable only within 90 days after infection. Pulmonary function abnormalities were most changed after influenza virus infection, and mean rapid change in FEV 1 (-118.5 ml) was significantly higher than expected (-15.2 ml, P = 0.03). Analysis of the period after the eight changes in the measured value of the change