论文部分内容阅读
以月桂烯为原料,与氯化氢反应生成香叶基氯及其同分异构体,产物与乙酰乙酸乙酯发生取代反应,经水解脱羧制得香叶基丙酮。月桂烯的加成反应是整个反应过程的关键步骤,对合成香叶基丙酮有决定性影响;重点探讨了催化剂种类及用量、反应温度及原料配比对月桂烯与氯化氢加成反应的影响。得到最适宜反应条件:以Cu Cl和四丁基溴化铵为催化剂,用量为月桂烯摩尔分数的1%,温度为10℃,n(月桂烯)∶n(氯化氢)=1∶1。该条件下,氯化物的产率可达92.86%,且香叶基氯和橙花基氯占氯化物总量的75.71%。氯化物经取代反应,水解脱羧后得到香叶基丙酮,产率为76.62%。
Myrcene as raw materials, and hydrogen chloride to generate geranyl chloride and its isomers, the product with ethyl acetoacetate substitution reaction, hydrolysis decarboxylation geranyl acetone. The addition reaction of myrcene is the key step in the whole reaction process, which has a decisive influence on the synthesis of geranyl acetone. The effects of the type and amount of catalyst, reaction temperature and the ratio of raw materials on the addition reaction of myrcene and hydrogen chloride are mainly discussed. The most suitable reaction conditions were as follows: CuCl and tetrabutylammonium bromide were used as catalysts, the amount of which was 1% of the mole fraction of myrcene, the temperature was 10 ℃, n (myrcene): n (hydrogen chloride) = 1: 1. Under this condition, the yield of chloride reached 92.86%, and the geranyl chloride and neryl chloride accounted for 75.71% of the total chloride. Chloride by substitution reaction, hydrolysis decarboxylation geranyl acetone, a yield of 76.62%.