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目的观察具有健脾益气、调肝解毒活血之效的糖肝康,对CCl4所致慢性肝损伤大鼠肝功能、炎性因子及氧化应激相关指标的影响。方法用腹腔注射40%CCl4的方法建立慢性肝损伤大鼠模型,并分为4组(n=10):模型对照组、糖肝康小剂量与大剂量组、降糖甲对照组,另加空白对照组(n=10),分别灌胃。药物干预12周后,观察糖肝康对慢性肝损伤大鼠TNF-α、IL-6、SOD、MDA及其肝功能的影响。结果糖肝康不仅可以使慢性肝损伤大鼠ALT、AST水平明显降低,还能有效地降低肝损伤大鼠的炎性因子TNF-α、IL-6和氧化应激相关指标SOD、MDA的水平。结论糖肝康对大鼠肝功能有明显的保护作用,其作用机制可能与其下调炎性因子TNF-α、IL-6的水平及抑制氧化应激有关。
Objective To observe the effect of Tanggankang, which has the effects of invigorating the spleen and invigorating Qi, regulating the liver and detoxifying the blood, on the liver function, inflammatory factors and indexes related to oxidative stress in rats with chronic liver injury induced by CCl4. Methods The rat model of chronic liver injury was established by intraperitoneal injection of 40% CCl4 and divided into 4 groups (n = 10): model control group, Tanggikang low dose and high dose group, hypoglycemic control group, plus Blank control group (n = 10), respectively, gavage. After 12 weeks of drug intervention, observe the effect of Tanggankang on TNF-α, IL-6, SOD, MDA and liver function in rats with chronic hepatic injury. Results Tanggankang can not only significantly reduce the level of ALT and AST in rats with chronic liver injury, but also can effectively reduce the levels of inflammatory cytokines TNF-α, IL-6 and oxidative stress related indexes SOD and MDA in liver injury rats . Conclusion TangGanKang can obviously protect the liver function of rats, and its mechanism may be related to down-regulating the levels of TNF-α and IL-6 and inhibiting the oxidative stress.