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１９９１～１９９７年的田间试验示范表明，巨峰葡萄在少雨年份发病较轻，易于控制，在多雨年份发病较重，通过合理的化学药剂组合防治可有效控制。防治巨峰葡萄主要病害效果最佳的化学药剂组合是，萌芽期以石硫合剂和五氯酚钠混合使用消灭越冬病菌；展叶期至花前主要防治灰霉病和黑痘病，以代森锰锌和多菌灵交替使用较好；花后至硬核期主要防治黑痘病、炭疽病和霜霉病，以代森锰锌、退菌特、炭疽福美、波尔多液交替使用最好；果实上色期以波尔多液、百菌清、炭疽福美、甲霜灵交替使用防治炭疽病、霜霉病等效果为佳；果实采收后用波尔多液防病保叶效果较好。
From 1991 to 1997, field experiments showed that Kyoho grapes were mild in incidence and easy to control in rainy years, with heavier incidence in rainy years and could be effectively controlled by reasonable combination of chemical agents. Prevention and treatment of Kyoho grapes the main disease is the best combination of chemical agents is the germination of sulfur sulfur and sodium pentachlorophenol in the use of mixed to eliminate overwintering germs; leaf blossoms to flower before the main prevention and control of gray mold and acne disease to dew Mn-Zn and carbendazim were better used alternately; antheraea and downy mildew were the main control from anthesis to anthracnose after anthesis, with the best use of mancozeb, bacteriocin, anthrax, and Bordeaux mixture; Fruit color to Bordeaux mixture, chlorothalonil, anthrax Fumei, metalaxyl alternate use of anthracnose prevention and control, downy mildew and other effects is better; Bordeaux mixture after harvest fruit leaf protection effect is better.