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多年临床实践表明,部分不明原因而有肝损伤的病人,用现有甲～戊型肝炎病原学检查方法,不能查出其病因,遂促使人们不断探索新的嗜肝性病毒。正当己型肝炎病毒及庚型肝炎病毒的认识热浪一涌而过之际,日本学者Nishizawa等通过详细的流行病学观察及代表性差异分析(representational difference analysis,RDA)从一个输血后肝炎病人中克隆到一个500bp的片段(N22),通过分子流行病学研究,证实了N22与输血后肝炎的高度特异性相关,并把该基因片段可能代表的病毒,以病人名字的首字母命名为TTV,从而揭开了TTV研究的序幕。随后Okamato等测定了TTV的全部基因序列,并分析了TTV在人群中的分布,首次系统地为人们展示了TTV的真面目。
Years of clinical practice have shown that in some patients with unexplained liver damage, the current etiological examination of hepatitis A and e can not find out the cause of the disease, thus prompting people to continually explore new hepadnavirus. Just as the heat waves of Hepatitis A and Hepatitis G viruses have surged, Japanese scholar Nishizawa and others, through detailed epidemiological observations and representational difference analysis (RDA) from a post-transfusion hepatitis patient A 500 bp fragment (N22) was cloned and confirmed by molecular epidemiological studies that N22 is highly specific for hepatitis B virus after transfusion. The virus, which may be represented by this gene fragment, is named TTV by the first letter of the patient’s name, Thus opened the prelude to TTV research. Subsequently, Okamato et al. Determined the entire TTV gene sequence and analyzed the distribution of TTV in the human population, for the first time systematically showed the true face of TTV.