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采用分子杂交技术对28例慢性肝病患者进行肝组织和血清HBV对比研究,结果表明:①肝组织HBV DNA阳性率显著高于血清HBV DNA阳性率,②血清DNA-P反映乙肝病毒的早期复制;③血清HBeAg阴性、Anti-HBe阳性时肝组织内可发现游离型HBV DNA及小片段DNA,表明肝内HBV正处于活跃复制状态,从分子水平证实了Anti-HBe阳性时部分患者可有传染性,需积极有效治疗:④慢迁肝和慢活肝中发现整合型HBV DNA较少,提示慢活肝经治疗后有希望达到从肝内清除乙肝病毒的目的。另外,也提示乙肝病毒在肝内的复制状态与病理损伤无直接关系。
The molecular hybridization technique was used to compare the serum HBV and HBV in 28 patients with chronic liver disease. The results showed that: (1) The positive rate of HBV DNA in liver tissues was significantly higher than that of serum HBV DNA; (2) The serum DNA-P reflected the early replication of hepatitis B virus; ③ Serum HBeAg negative, Anti-HBe positive liver tissue can be found in free HBV DNA and small fragments of DNA, indicating that intrahepatic HBV is in an active replication state, confirmed from the molecular level of Anti-HBe positive when some patients may be infectious , The need for active and effective treatment: ④ slowly moving liver and slow liver found in integrated HBV DNA less, suggesting that slow-living liver after treatment there is hope to achieve the purpose of removing hepatitis B virus from the liver. In addition, it is also suggested that hepatitis B virus replication status in the liver and pathological injury is not directly related.