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妊娠期糖尿病(GDM)是糖尿病的一种特殊类型,对孕妇和胎儿都有不利影响,GDM患者糖代谢多数于产后能恢复正常,但将来患2型糖尿病的机会增加。GDM的发生可能与多种因素有关,其中炎性反应与胰岛素抵抗有着密切关系。细胞因子是细胞应对各类刺激而分泌的小分子蛋白,包括白细胞介素、肿瘤坏死因子、集落刺激因子、生长因子等,可参与多种炎性反应,可能是促进胰岛素抵抗的一个重要因素,在GDM的发生和发展中起重要作用。对细胞因子与GDM的研究有助于了解GDM的发病机制,并为预防和治疗GDM提供理论依据,以降低2型糖尿病的发生率。
Gestational diabetes mellitus (GDM) is a special type of diabetes that has adverse effects on pregnant women and fetus. Most of the patients with GDM have normal glucose metabolism after delivery, but the chances of developing type 2 diabetes will increase in the future. The occurrence of GDM may be related to a variety of factors, including inflammatory response and insulin resistance are closely related. Cytokines are small molecules secreted by cells to stimulate various stimuli, including interleukin, tumor necrosis factor, colony stimulating factor, growth factor, etc. They may participate in many inflammatory reactions and may be an important factor to promote insulin resistance. Play an important role in the occurrence and development of GDM. Research on cytokines and GDM will help to understand the pathogenesis of GDM and provide a theoretical basis for the prevention and treatment of GDM to reduce the incidence of type 2 diabetes.