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神经轴突导向分子Netrin-1通过与其受体结直肠癌缺陷基因(deleted in colorectal cancer,DCC)或UNC5同源物(UNC-5Homolog,UNC5A-C,UNC5H1-3)家族成员结合传递信号,参与神经轴突的生长、定向迁移和神经元发育等生理功能。Netrin-1受体在没有配体结合的情况下,诱导细胞凋亡,故被归为“依赖性受体”(dependence receptor,DR)家族。Netrin-1受体在结直肠癌等多种肿瘤中下调或不表达,导致其表达下调的可能机制包括杂合性缺失、表观遗传学改变和转录调控等;过表达Netrin-1受体可抑制肿瘤细胞的增殖和迁移。Netrin-1及其受体家族是近年来鉴定出来的肿瘤参与分子,很可能是未来肿瘤治疗的新靶点。
Netrin-1, a neurotransmitter-directed molecule, transmits signals by binding to its receptor deleted members of the family of members of the CRC (DCC) or UNC5 homolog (UNC-5Homolog, UNC5A-C, UNC5H1-3) Neuronal axon growth, directional migration and neuronal development and other physiological functions. The Netrin-1 receptor induces apoptosis in the absence of ligand binding and is therefore classified as a “dependent receptor” (DR) family. Netrin-1 receptor may be down-regulated or not expressed in many tumors such as colorectal cancer, which may result in the loss of heterozygosity, epigenetic changes and transcriptional regulation. Netrin-1 receptor may be overexpressed Inhibit tumor cell proliferation and migration. Netrin-1 and its receptor family is a tumor-associated molecule identified in recent years, which is likely to be a new target for future cancer treatment.