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目的：了解CyclinD1基o表达产物（p36D1）与．大肠癌发生和进展的关系。方法：应用改良Westernblot法和免疫组化法检测33例肠道对物（大肠癌29例，癌前病变4例）及其非瘤粘膜组织CycliflD1基因产物的表达；井采用LUZeX－F图像分析仪对安验结果进行半之妻分析。结果：了厂卜。linD；基因产物在大肠癌组织、名前病变组织及非瘤粘膜组织有不同表达；②CycllnD；过表达与大肠在浸染深度、生物恶性度及从巴转移率呈正相关，与临床在函分期有共；③右前在生恶化Cy－clinD；这表达；＠XycllnD；过人达与大肠涛临床痴理分期及预后有关。结论：CyCllnD；基0：达与大肠癌发生、进名及恶性产产切相望，可能是全要的预后因子。
Objective: To understand the expression of CyclinD1-based o (p36D1) and. The relationship between the occurrence and progression of colorectal cancer. METHODS: The expression of CycliflD1 gene products in 33 cases of intestinal metastases (29 cases of colorectal cancer, 4 cases of precancerous lesions) and non-tumorous mucosal tissues was detected by modified Western blot and immunohistochemistry; the LUZeX-F image analyzer was used. A semi-wife analysis of the test results. Result: Factory Bu. linD; Gene products have different expressions in colorectal cancer, premalignant tissue and non-tumor mucosal tissue; 2CycllnD; overexpression is positively correlated with the depth of colon in the infection, biological malignancy, and metastasis from Bacillus, and is common with the clinical stage in letters; 3 The right frontal exacerbation of Cy-clinD; this expression; @XycllnD; Guorenda is related to clinical staging and prognosis of Dachang Tao. Conclusion: CyClInD; basal 0: up to reach the occurrence of colorectal cancer, entry into the name and malignant neonatal production on the other hand, may be a prognostic factor.