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目的:应用超声观察原发性高血压(EH)患者颈动脉内膜-中层厚度(IMT),并探讨其冠状动脉内皮功能及两者的相关性。方法:选择60例EH患者(EH组)、30例健康体检者(正常对照组),测定其颈动脉IMT及冷加压试验前后冠状动脉左主干内径变化百分率。结果:EH患者颈动脉IMT较正常对照组增厚,冷加压试验冠状动脉左主干内径变化百分率明显低于正常对照组。颈动脉IMT与冷加压试验冠状动脉左主干内径变化呈显著负相关。结论:EH患者存在明显的颈动脉IMT增加及冠状动脉内皮功能减低。
Objective: To observe the carotid intima - media thickness (IMT) in patients with essential hypertension (EH) by ultrasound and investigate the correlation between the endothelial function and coronary artery endothelial function. Methods: Sixty EH patients (EH group) and 30 healthy subjects (EH group) were selected. The changes of carotid artery IMT and the left main coronary artery diameter before and after cold compression were measured. Results: The IMT of carotid artery in patients with EH was thicker than that of normal control group. The percentage change of left main artery diameter in cold compression test was significantly lower than that of normal control group. There was a significant negative correlation between carotid IMT and changes of left main coronary artery diameter in cold compression test. Conclusion: There is significant increase of carotid IMT and decrease of endothelial function in patients with EH.