多靶点治疗膜性相关狼疮性肾炎的疗效观察

• 作 者: 唐泰
• 机 构: 广西壮族自治区桂东人民医院肾内科,
• 出 处: 临床医学
• 发表日期: 2016年07期
• 关键词: 多靶点 系统性红斑狼疮 狼疮性肾炎

目的观察多靶点治疗膜性相关狼疮性肾炎的临床效果和安全性。方法 80例系统性红斑狼疮患者经肾活检确诊为膜性相关狼疮性肾炎,给予他克莫司、环磷酰胺、羟氯喹联合泼尼松治疗,观察患者治疗前、治疗3个月及6个月后的24 h尿蛋白定量、血清白蛋白、血清补体C3水平、SLE-DAI积分。结果治疗3个月后,有23例患者达到完全缓解,27例达部分缓解,总缓解率64.9%;治疗6个月后,有34例患者达到完全缓解,32例达部分缓解,总缓解率88%。结论多靶点治疗能有效降低膜性相关狼疮性肾炎的蛋白尿、升高血清白蛋白,提高患者的缓解率,降低药物不良反应的发生率。

Objective To observe the clinical effect and safety of multi-target therapy for membranous lupus nephritis. Methods Totally 80 patients with systemic lupus erythematosus were diagnosed as membranous lupus nephritis by renal biopsy and received tacrolimus, cyclophosphamide and hydroxychloroquine combined with prednisone. Before treatment, the patients were treated for 3 months and 6 24 h urine protein after a month, serum albumin, serum complement C3 levels, SLE-DAI score. Results After 3 months of treatment, 23 patients achieved complete remission and 27 achieved partial remission with a total response rate of 64.9%. After 6 months of treatment, 34 patients achieved complete remission and 32 achieved partial remission with a total response rate 88%. Conclusion Multi-target therapy can effectively reduce the proteinuria of membranous lupus nephritis, raise serum albumin, improve the remission rate and reduce the incidence of adverse drug reactions.