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目的观察妈富隆治疗多囊卵巢综合征(PCOS)不孕患者的疗效。方法选择2011年2月至2012年6月在我院就诊PCOS患者72例,随机分为两组:观察组38例,口服妈富隆3个周期;对照组34例,黄体酮撤退出血3个周期。比较用药3个月后血清卵泡刺激素(FSH)、黄体生成素(LH)和睾酮(T)、卵巢体积和窦卵泡数。然后两组均用克罗米芬(CC)促排卵。停药后比较观察组和对照组的周期排卵率。结果妈富隆治疗后血清LH、FSH、LH/FSH、T、双侧卵巢体积、窦卵泡个数均较治疗前及与对照组比较明显下降(P<0.01)。观察组的周期排卵率、妊娠率高于对照组。结论妈富隆是治疗PCOS不孕的有效方法 。
Objective To observe the effect of Marvelon in the treatment of infertility with polycystic ovary syndrome (PCOS). Methods 72 patients with PCOS who were treated in our hospital from February 2011 to June 2012 were randomly divided into two groups: observation group (38 cases) and oral Marvelon (3 cycles); control group (34 cases), progesterone withdrawal bleeding for 3 cycles . Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T), ovarian volume and the number of antral follicles were compared 3 months after treatment. Both groups then used clomiphene citrate (CC) to induce ovulation. After stopping treatment, the ovulation rate of the observation group and the control group were compared. Results After treatment with Marvelon, the serum LH, FSH, LH / FSH, T, bilateral ovarian volume and the number of antral follicles were significantly decreased compared with before treatment and control group (P <0.01). The observation group’s cycle ovulation rate, pregnancy rate was higher than the control group. Conclusion Marvelon is an effective treatment of PCOS infertility.