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目的：探讨尿中ＩＬ┐６测定在系膜增殖性肾炎（ＭｓＰＧＮ）病理诊断、病程监测中的意义。方法：应用生物活性法测定３０例ＭｓＰＧＮ患儿及１５例非系膜增殖性肾炎（Ｎ┐ＭｓＰＧＮ）患儿尿中ＩＬ┐６活性，同时分析其与ＭｓＰＧＮ病理改变的关系。结果：ＭｓＰＧＮ组尿中ＩＬ┐６活性较Ｎ┐ＭｓＰＧＮ组显著增高，中度ＭｓＰＧＮ尿ＩＬ┐６活性较轻度ＭｓＰＧＮ显著增高，且与ＭｓＰＧＮ病理程度密切相关。结论：尿中ＩＬ┐６活性的测定能间接反映肾脏病变类型及程度，监测尿中ＩＬ┐６活性对ＭｓＰＧＮ病理诊断的预计有重要意义
Objective: To investigate the significance of urinary IL ┐ 6 determination in the pathological diagnosis and duration of mesangial proliferative glomerulonephritis (MsPGN). Methods: Urinary IL-6 activity was measured by bioassay in 30 cases of MsPGN and 15 cases of non-proliferative nephritis (N┐MsPGN). Meanwhile, the relationship between IL-6 and MsPGN pathological changes was analyzed. Results: The urinary IL┐6 activity in MsPGN group was significantly higher than that in N┐MsPGN group, while the urinary IL┐6 activity in moderate MsPGN group was significantly higher than that of mild MsPGN group, which was closely related to the pathological grade of MsPGN. Conclusion: The determination of urinary IL ┐ 6 activity can indirectly reflect the type and extent of renal lesions. Monitoring urinary IL ┐ 6 activity is of great significance for the prediction of MsPGN pathological diagnosis