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含葡萄糖的注射液灭菌后 pH 值有所下降,尤其是葡萄糖氯化钠注射液(以下简称 GNS)下降明显,本文就其下降原因进行分析。一、pH 下降与5-HMF 的关系含葡萄糖的注射液灭菌后 pH 下降是因为葡萄糖在弱酸性下热压灭菌时部分分解成5-HMF,后者又进一步分解成甲酸和乙酰丙酸等有机酸及有色物质,生成的5-HMF 越多进而分解成有机酸的可能也越多,因此
The pH value of glucose-containing injection decreased after sterilization, especially glucose and sodium chloride injection (hereinafter referred to as GNS) decreased significantly, the reasons for the decline of this paper analysis. First, the relationship between pH drop and 5-HMF Degradation of pH after glucose-containing injection of glucose is due to partial decomposition of glucose under weak acid autoclaving into 5-HMF, which is further broken down into formic acid and levulinic acid Such as organic acids and colored materials, the more 5-HMF generated and thus more organic acids may be broken down, so