论文部分内容阅读
Sjogren’s综合征(下简称Sjs)是一种以外分泌腺体慢性炎症为主的胶原病近缘性疾病,其发病之实质为免疫调节平衡失调致使发生自身免疫现象的结果。其主要临床表现为:1.涎腺萎缩:涎液分泌减少;涎液电解质异常(如钠离子明显增高);涎液免疫球蛋白异常(如分泌型IgA明显增高);口干、舌乳头萎缩、吞咽困难、猖獗性龋;涎腺造影示腺房及终末腺管扩张、腺管数减少;涎腺放射性同位素闪烁扫描(常用的是~(99m)锝)示对同位素之摄取、积聚、排泄均见减少;下唇唇腺活组织检查示腺管周围、腺实质大量淋巴细胞浸润、腺实质萎缩、腺管上皮细胞、
Sjogren’s syndrome (hereinafter referred to as Sjs) is a peripheral inflammation of the collagen secretion of chronic inflammation-based disease, the incidence of the essence of the balance of immune regulation imbalance resulting in the phenomenon of autoimmune results. The main clinical manifestations are: 1. salivary gland atrophy: salivation decreased; salivary fluid electrolyte abnormalities (such as sodium was significantly higher); salivary fluid immunoglobulin abnormalities (such as secretory IgA was significantly higher); dry mouth, tongue papillary atrophy , Dysphagia, rampant caries; salivary gland angiography showed the dilatation of the gland and terminal ducts, reduced duct count; salivary gland radiofrequency scintigraphy (commonly used ~ (99m) technetium) shows the isotope uptake, accumulation, Excretion are reduced; lower lip labial gland biopsy showed around the gland, a large number of glandular lymphocyte infiltration, gland atrophy, glandular epithelial cells,