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目的探讨尼美舒利干悬混剂联合利多卡因胶浆在人工流产中的应用效果及安全性。方法选择2014年1月至2015年5月东莞市长安医院妇科门诊要求人工流产妇女300例,将其分为3组,每组各100例,A组(观察组)采用尼美舒利干悬混剂联合利多卡因胶浆;B组采用静脉全麻(丙泊酚注射液+酒石酸布托啡诺注射液);C组采用传统人工流产,不用任何药物。比较3组宫颈扩张、镇痛效果、出血量及人工流产综合反应。结果 A组宫颈扩张效果、镇痛效果及人工流产综合反应情况与C组比较差异有统计学意义(P<0.017);A组出血量与C组比较差异无统计学意义(P>0.017)。A组和B组镇痛有效率分别为92%、100%,宫颈扩张显效率分别为81%、17%,人工流产综合反应发生率分别为19%、86%,出血量分别为[(14.40±2.69)m L、(25.13±2.42)m L](P<0.017)。结论尼美舒利干悬混剂联合利多卡因胶浆应用于人工流产安全有效,值得临床进一步应用和开展。
Objective To investigate the effect and safety of nimesulide suspension combined with lidocaine mortar in induced abortion. Methods From January 2014 to May 2015, 300 gynecological clinics were conducted in Chang’an Hospital of Dongguan City, which were divided into three groups of 100 cases each. Group A (observation group) Mixture of lidocaine glue; B group using intravenous anesthesia (propofol injection + Butorphanol tartrate injection); C group using traditional abortion, without any drug. Compare the three groups of cervical dilation, analgesic effect, bleeding and abortion comprehensive response. Results The results of cervical dilatation, analgesic effect and induced abortion in group A were significantly different from those in group C (P <0.017). There was no significant difference in bleeding between group A and group C (P> 0.017). The analgesic efficacies in group A and group B were 92% and 100%, respectively. The effective rates of cervical dilatation were 81% and 17% respectively. The incidences of combined abortion and induced abortion were 19% and 86% ± 2.69) m L, (25.13 ± 2.42) m L] (P <0.017). Conclusion Nimesulide suspension combined with lidocaine mortar applied to the safe and effective abortion, it is worth further clinical application and development.