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AIM:To study the bioadhesive property of carbomer934 indog alimentary tract.METHODS:Carbomer934 and ethylcallulose wereradiolabelled with technetium-99m;and gastrointestinalemptying rate of materials was measured using thetechnique of gamma scintigraphy.RESULTS:After oral administration,the maximum intestinalradioactivity of non-bioadhesive granules and bioadhesivegranules were observed in the second hour and the sixthhour respectively.Constants of stomach emptying rate ofnonadheaive granules,bioadhesive granules Ⅰ andbioadhesive granules Ⅱ were 0.774h~(-1),0.265h~(-1)and0.321h~(-1)respectively on the base of gastric residualamount.Compared to nonadhesive material(ethylcellulose),the migration rate of adhesive material(carbomer934)was remarkably slower in dog alimentarycanal.CONCLUSION:It is concluded that,in the dog,interactionsbetween gastrointestinal mucus layer and adhesive materialor nonadhesive material were significantly different.Carbomer934 had stronger in vivo bioadhesive property thanethylcellulose.
AIM: To study the bioadhesive property of carbomer 934 indog alimentary tract. METHODS: Carbomer 934 and ethylcallulose wereradiolabelled with technetium-99m; and gastrointestina lemming rate of materials was measured using the technique of gamma scintigraphy .RESULTS: After oral administration, the maximum intestinal activity of non-bioadhesive granules and bioadhesivegranules were observed in the second hour and the sixth hour respectively.Constants of the stomach emptying rate ofnonadheaive granules, bioadhesive granules Ⅰandbioadhesive granules Ⅱ were 0.774h ~ (-1), 0.265h ~ (-1) and0.321h ~ (- 1) respectively on the base of gastric residualamount. Compared to nonadhesive material (ethylcellulose), the migration rate of adhesive material (carbomer 934) was remarkably slower in dog alimentarycanal. CONCLUSION: It is said that, in the dog, interactions between gastrointestinal mucus layer and adhesive materialor nonadhesive material were significantly different. Carbomer934 had stronger in vivo bioadhesive property thanethylcellulose.