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本文证明了: 1、将1∶1的延安桃仁混合药材(山桃仁10％,家桃仁90％)煎剂(下同),给小白鼠一次灌胃,0.2克/10克体重,可使小白鼠出血时明显延长,但对凝血时无显著影响。 2、将延安山桃仁与家桃仁分别制成1∶1煎剂,给小白鼠分别灌胃,药量同上,每天一次,连用10—11天后,单纯的家桃仁煎剂可使小白鼠出血时非常显著地延长,对凝血时延长不明显,而单纯的山桃仁煎剂可使小白鼠的凝血时非常显著地延长,但对出血时的影响不明显。说明二者均能影响血液凝固过程,但二者作用有差别。 3、给家兔灌以1∶1山桃仁煎剂,每天一次,每次2.5毫升/公斤体重,连灌7—8天,可显著延长家兔的出血时、血浆复钙时间,并能非常显著地延长其凝血时与凝血酶元时间,并完全抑制其血块回缩。
This article has proved: 1, the 1: 1 Yanan peach kernel mixed herbs (10% peach, peach kernel 90%) decoction (the same below), to mice once gavage, 0.2 g / 10 g body weight, can make small Obvious prolongation of bleeding in rats, but no significant effect on coagulation. 2, the Yanan Shan Tao Ren and home peach were made into 1: 1 decoction, to mice were gavage, the same dose as above, once a day, once every 10-11 days, pure home peach decoction can make mice bleeding Very significantly prolonged, the coagulation time is not obvious, and simple Shan Taoren decoction can make the mouse clot very significantly prolonged, but the bleeding was not obvious. Explain that both can affect the blood coagulation process, but the difference between the two. 3, to the rabbit irrigation with 1: 1 Shanxi peach decoction once a day, each 2.5 ml / kg body weight, even irrigation 7-8 days, can significantly extend the rabbit bleeding, the plasma calcium complex time, and can be very It significantly prolonged its clotting time and thrombin time, and completely inhibited the clot retraction.