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目的:观察红花黄色素粉针与氯沙坦钾片(科索亚)联合治疗早期糖尿病肾病(DN)的疗效。方法:将早期DN 60例随机分为治疗组和对照组各30例。对照组每天予氯沙坦钾每次50mg,每天1次;治疗组在对照组用药基础上,加用红花黄色素粉针100mg加入生理盐水100ml中静脉滴注,每天1次,15天为1个疗程,共1个疗程。观察两组血糖、尿清蛋白排泄率、血肌酐、尿素氮等水平变化。结果:治疗组总有效率83.3%,显著高于对照组总有效率的56.7%(P<0.05)。治疗组治疗后FBG、UAER、BUN、Cr水平显著低于对照组(P<0.05)。结论:红花黄色素粉针与氯沙坦钾片联合治疗早期DN,在减少尿蛋白,改善肾功能方面明显优于单用氯沙坦钾片。
Objective: To observe the curative effect of safflower yellow powder injection and Losartan potassium tablets (Kosovae) in the treatment of early diabetic nephropathy (DN). Methods: The early DN 60 cases were randomly divided into treatment group and control group of 30 cases. The control group was given losartan potassium 50mg once daily for one day. In the treatment group, 100mg of safflower yellow powder injection was added to 100ml of normal saline intravenously on the basis of the control group, once a day for 15 days 1 course of treatment, a total of 1 course of treatment. The changes of blood glucose, urinary albumin excretion rate, serum creatinine and urea nitrogen were observed. Results: The total effective rate in the treatment group was 83.3%, significantly higher than that in the control group (56.7%, P <0.05). After treatment, the levels of FBG, UAER, BUN and Cr in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion: The combination of safflower yellow powder injection and losartan potassium tablets in the treatment of early DN is obviously superior to losartan potassium tablets in reducing urinary protein and improving renal function.