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利用单链ＤＮＡ分子共价固定在石墨电极表面，采用核酸分子杂交技术，以道诺霉素作为杂交指示剂形成ＤＮＡ电化学传感器．研究了在不同致突变剂的作用下，特定碱基序列的ＤＮＡ在电极表面能否杂交及杂交程度的差异，探讨了ＤＮＡ突变情况及可能的突变机理．
Single-stranded DNA molecules were covalently immobilized on the surface of graphite electrodes, and nucleic acid hybridization was used to form DNA electrochemical sensors with daunomycin as a hybridization indicator. The effects of different mutagens on DNA hybridization and hybridization on the electrode surface were investigated. The DNA mutation and possible mutation mechanism were investigated.