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罗伯逊重排是主要先天性染色体结构异常中一种最常见的类型。在连续观察的562名新生儿中,51人(0.09%)有罗伯逊重排,频率为每1 117名新生儿中有1个。罗伯逊重排还有其他一些特征。在出现罗伯逊重排全部物种中,它们都是自然发生的。它们的形成不可能被电离辐射或化学诱变剂所诱导。近端着丝粒常染色体发生罗伯逊重排是高度非随机的,13～15号染色体间的重排,有累及13号和14号染色体的趋势,从而导致(13q;14q)重排。13～15组染色体和21号或22号染色体间的重排,趋向于累及14号和
Robertson rearrangement is one of the most common types of structural abnormalities in the major congenital chromosomes. Of the 562 newborns observed consecutively, 51 (0.09%) had Robertson rearrangements at a frequency of 1 in 117 children. There are other features of Robertson rearrangement. All occur naturally in Robertson rearrangement of all species. Their formation can not be induced by ionizing radiation or chemical mutagens. Nearly centromeric autosomal Robertson rearrangements are highly nonrandomized rearrangements of chromosomes 13-15 and have a tendency to affect chromosomes 13 and 14, resulting in (13q; 14q) rearrangements. The rearrangements between chromosomes 13-15 and chromosome 21 or 22 tend to affect chromosome 14 and