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目的探讨不同药物在宫颈上皮内瘤变(Cervical Intraepithial Neoplasia,CIN)环形电切除术(Loop Electrosurgical Excision Procedure,LEEP)术后的疗效。方法将113例CIN患者随机分为辛复宁(重组人干扰素α-2b阴道泡腾胶囊)组、爱杰特(纳米银妇女外用抗菌凝胶)组和对照组,均行LEEP术,术后给予口服抗生素48 h预防感染。辛复宁组和爱杰特组分别给予辛复宁、爱杰特阴道后穹窿上药3个疗程,对照组常规处理,观察3组患者术后创面愈合时间、伴随症状持续时间、术后并发症、人乳头瘤状病毒转阴率。结果辛复宁组、爱杰特组和对照组在愈合时间、伴随症状持续时间、并发症发生率、HPV转阴率等方面存在不同程度差异,其中辛复宁在以上各方面均存在优势。结论 CIN术后阴道局部用药治疗对术后恢复有积极意义;辛复宁明显缩短了创面愈合时间并减少了并发症的发生,提高了HPV转阴率,值得临床推广。
Objective To investigate the efficacy of different drugs after the operation of Cervical Intraepthial Neoplasia (CIN) Loop Electrosurgical Excision Procedure (LEEP). Methods 113 patients with CIN were randomly divided into Xin Fu Ning (recombinant human interferon α-2b vaginal effervescent capsules) group, love Jie Te (nano-silver women external antimicrobial gel) group and the control group, were performed LEEP surgery, postoperative Oral antibiotics 48 h to prevent infection. Xin Fu Ning group and Ai Jie Te group were given Xin Fu Ning, Ai Jiete vaginal fornix on the drug three courses, the control group routine treatment, observation of the three groups of patients with wound healing time, with symptoms duration, postoperative complications, the human papilla Tumor virus negative rate. Results Xin Fu Ning group, Ai Jie Te group and control group in the healing time, with the duration of symptoms, the incidence of complications, HPV negative conversion rate there are different degrees of difference, of which Xin Fu Ning in all the above aspects have advantages. Conclusion The vaginal topical application of CIN has a positive effect on postoperative recovery. Xinfuning significantly shortened the wound healing time and reduced the incidence of complications, and increased the rate of HPV negative conversion, which is worthy of clinical promotion.