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目的:探讨黄芪提取物对局灶脑缺血再灌注损伤的保护作用及其机制。方法:采用MCAO(大脑中动脉阻塞法)制备局灶性脑缺血动物模型,然后将SD大鼠随机分为假手术组、模型组、黄芪提取物组(AST组,80mg·kg-1)、尼莫地平组(0.5 mg·kg-1),用药后,观察药物对脑缺血引起的神经功能缺损症状以及脑组织内NO含量的影响。结果:黄芪提取物组不仅能减轻大鼠的神经功能缺损症状;通过治疗后,各治疗组大鼠大脑皮质神经元病变有一定程度的改善。结论:黄芪提取物对脑缺血再灌注损伤有一定保护作用,其作用机制可能与降低NO浓度,达到减少对脑组织的刺激而产生作用。
Objective: To investigate the protective effect of Astragalus extract on focal cerebral ischemia-reperfusion injury and its mechanism. Methods: The animal model of focal cerebral ischemia was established by MCAO (middle cerebral artery occlusion) method. Then SD rats were randomly divided into sham operation group, model group, Astragalus extract group (AST group, 80 mg · kg -1) , And nimodipine (0.5 mg · kg-1). After treatment, the effects of drugs on neurological deficits induced by cerebral ischemia and NO content in brain tissue were observed. Results: Astragalus extract group can not only alleviate the symptoms of neurological deficit in rats, but also improve the cerebral cortex neurons in all treatment groups after treatment. CONCLUSION: Astragalus extract has a protective effect on cerebral ischemia-reperfusion injury. Its mechanism of action may be related to the decrease of NO concentration and the reduction of brain stimulation.