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用Ｐｕｌｓｉｎｅｌｉ四动脉结扎法造成大鼠急性脑缺血再灌损伤，观察槲皮素磷酸酯钾的保护作用并探讨其机制。结果表明：静脉注射槲皮素磷酸酯钾２０ｍｇ／ｋｇ可降低脑钙及丙二醛含量，减轻脑水肿并缓解脑损伤引起的乳酸脱氢酶释放，改善脑电图的抑制和脑组织的病理损伤，提示本品对脑缺血再灌损伤具有保护作用，其机制可能与防止脑细胞钙超载和抗脂质过氧化有关。
Acute cerebral ischemia-reperfusion injury was induced by Pulsineli four-artery ligation in rats. The protective effect of quercetin potassium phosphate and its mechanism were observed. The results showed that intravenous injection of quercetin potassium phosphate 20mg / kg can reduce the content of brain calcium and malondialdehyde, reduce cerebral edema and relieve brain injury caused by the release of lactate dehydrogenase to improve the inhibition of EEG and brain tissue pathology Injury, suggesting that this product has a protective effect on cerebral ischemia-reperfusion injury, the mechanism may be related to preventing calcium overload and anti-lipid peroxidation of brain cells.