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细胞膜液体流动性担负细胞许多重要生理功能,其流动性依赖于磷脂的不饱和脂肪酸的数量,而与磷脂中的胆固醇、饱和脂肪酸含量成反比。细胞年龄增长和外来刺激引起膜脂类的氧化,能改变膜液体流动性及功能。不饱和脂肪酸是较大的基质,参与氧化作用与血栓素形成,而膜中脂类氧化过程中产生的过氧化物则抑制前列环素的合成。 血栓素A_2(TXA_2)和前列环素(PGI_2)的失衡已被认为是妊高症的致病因素之一。同时血小板
Liquid fluidity of the cell membrane is responsible for many important physiological functions of the cell. Its fluidity depends on the amount of unsaturated fatty acids in the phospholipid but inversely proportional to the cholesterol and saturated fatty acid content in the phospholipid. Cell aging and external stimuli caused by membrane lipid oxidation, can change the liquid membrane fluidity and function. Unsaturated fatty acids are larger substrates involved in oxidation and thromboxane formation, while peroxides produced during lipid oxidation in the membrane inhibit prostacyclin synthesis. The imbalance between thromboxane A 2 (TXA 2) and prostacyclin (PGI 2) has been considered as one of the causative agents of pregnancy induced hypertension. At the same time, platelets