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选取我院2012年3月~2014年10月收治的98例动脉瘤性蛛网膜下腔出血行颅内动脉瘤介入治疗患者。随机分为观察组和对照组各49例。对照组采用间断腰穿,观察组采用腰大池引流。对比分析两组患者脑脊液红细胞计数、脑脊液内皮素-1(ET-1)水平、大脑中动脉平均血流速度(VMCA)及术后14d神经功能缺损评分。结果观察组治疗3、5、7、10、14d脑脊液红细胞计数和ET-1水平均显著低于对照组,且具有统计学差异(P<0.05);观察组治疗3、5、7、10、14d的VMCA显著高于对照组,且具有统计学差异(P<0.05);观察组治疗14d后神经功能缺损评分显著低于对照组,且具有显著性意义(P<0.05)。腰大池引流在颅内动脉瘤介入治疗术后防治脑血管痉挛临床效果显著,具有重要临床研究价值。
A total of 98 patients with aneurysmal subarachnoid hemorrhage treated in our hospital from March 2012 to October 2014 were selected for interventional therapy of intracranial aneurysms. Randomly divided into observation group and control group of 49 cases. The control group with intermittent lumbar puncture, the observation group using the lumbar drainage. The cerebrospinal fluid erythrocyte count, cerebrospinal fluid endothelin-1 (ET-1) level, mean arterial blood flow velocity (VMCA) and neurological deficit score at 14 days were compared between the two groups. Results The erythrocyte count and ET-1 level in cerebrospinal fluid in observation group were significantly lower than those in control group on the 3rd, 5th, 7th, 10th and 14th days (P <0.05) The VMCA of the 14th day was significantly higher than that of the control group (P <0.05). The score of neurological deficit in the observation group after 14 days of treatment was significantly lower than that of the control group (P <0.05). Lumbar drainage in the intracranial aneurysm after interventional treatment of cerebral vasospasm clinical effect is significant, has important clinical research value.