Renal amyloidosis and hepatitis B virus-associated glomerulonephritis in a patient with nephrotic sy

• 作 者: Jiang Wei Xu Yan Guan Guangju
• 机 构: Shandong University, Jinan, Shandong 250014, China“,”Department of Nephrology, The Affiliated Hospit
• 出 处: 中华医学杂志（英文版）
• 发表日期: 2014年6期

To the editor:A 53-year-old woman presenting with eyelid edema,and foamy urine for a period of 3 years was admitted to the Qingdao Medical College Hospital.She had been a hepatitis B virus (HBV) carrier for 30 years.Upon admission,the 24-hour urinary protein quantity was 3.6 g.Plasma albumin level was 29 g/L.Serum amyloid A (SAA) level was 45 μg/ml.The renal biopsy results are given in Figure 1.Consequently,this case was diagnosed as secondary AA amyloidosis associated with HBV-associated glomerulonephritis (HBV-GN).We believed that HBV infection had a key role in amyloid deposition and heavy proteinuria.Lamivudine was administered orally at 100 mg/d.Six months later,the patient 24-hour urinary protein excretion was 1.0 g,and peripheral edema disappeared completely.