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一氧化氮 (ＮＯ)和内皮素 (ＥＴ)是调节肝星状细胞 (ＨＳＣ)收缩与舒张的重要因素。我们研究硝苯地平对ＨＳＣ分泌ＮＯ和ＥＴ的影响 ,探讨硝苯地平防治肝硬化门脉高压症的作用及其可能机制。一、材料与方法鼠肝星状细胞系ＨＳＣ Ｔ6 (美国旧金山总医院肝病研究中心Ｆｒｉｅｄｍ
Nitric oxide (NO) and endothelin (ET) are important factors that regulate the contraction and relaxation of hepatic stellate cells (HSCs). We investigated the effect of nifedipine on the secretion of NO and ET by HSC and the role of nifedipine in the prevention and treatment of cirrhotic portal hypertension and its possible mechanism. First, the material and methods Rat hepatic stellate cell line HSC T6 (San Francisco General Hospital Liver Disease Research Center Friedm