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β_2-微球蛋白(β_2-MG)怍为主要组织相容性抗原复合物(MHC)抗原Ⅰ的轻链,常表达在有核细胞膜上。近年认为,慢性肝炎时肝细胞损伤与T细胞毒性有关,因此,肝病变与β_2-MG间的相关性正在受到重视。但β_2-MG与HLA抗原Ⅰ(HLAI)的相关性尚未明确。为此,本文在于探讨慢性肝炎患者血清和肝组织内β_2-MG以及HLAI、CD_811~-细胞(TC)间的相关性。对象和方法:选择无肾功能障碍的慢性肝炎患者40例,其中乙型25例,非甲非乙型15例。根据施行肝活检时的转氨酶活性,将其分为上升期、下降期和稳定期3组。血清β_2-MG用EIA法检测,肝组织内β_2-MG,
β 2 -microglobulin (β_2-MG) 怍 is the light chain of the major histocompatibility antigen complex (MHC) antigen I, often expressed on nucleated cell membranes. In recent years, liver cell damage in chronic hepatitis and T cell toxicity, therefore, the correlation between liver disease and β_2-MG is receiving attention. However, the relationship between β 2-MG and HLA antigen I (HLAI) is not yet clear. To this end, this article is to explore the serum and liver tissue of patients with chronic hepatitis B 2 MG and HLAI, CD_811 ~ - (TC) between the correlation. PARTICIPANTS AND METHODS: Forty patients with chronic hepatitis without renal dysfunction were selected, of which 25 were type B and 15 were non-type A and non-type B. According to the transaminase activity during liver biopsy, it was divided into three groups: ascending phase, descending phase and stable phase. Serum β_2-MG was detected by EIA, β 2-MG,